產(chǎn)品詳情介紹
血小板源性生長(zhǎng)因子（Platelet-Derived Growth Factor，PDGF）是一種在多種生理和病理過(guò)程中起重要作用的細(xì)胞因子。PDGF由兩條不同的多肽鏈組成，通過(guò)二硫鍵連接成二聚體，這使PDGF具有三種形式的二聚體結(jié)構(gòu)，即PDGF-AA，PDGF-BB及PDGF-AB[1-3]。這些二聚體通過(guò)與兩種類型的受體（PDGFR-α和PDGFR-β）結(jié)合來(lái)激活細(xì)胞內(nèi)信號(hào)傳導(dǎo)途徑。PDGF-BB主要由血小板、巨噬細(xì)胞和肥大細(xì)胞產(chǎn)生，尤其在損傷后由血小板分泌。PDGF-BB作為一種有效的促有絲分裂因子，能夠促進(jìn)細(xì)胞的增殖和血管生成。另外PDGF-BB在腫瘤的生長(zhǎng)發(fā)育過(guò)程中起著重要的作用，它參與了腫瘤的血管生成，并且是腫瘤診斷和識(shí)別的重要生物標(biāo)志物[4-5]。
[1] Ross R. Platelet-derived growth factor. Annu Rev Med, 1987, 38:71-79.
[2] Heldin CH. Platelet-derived growth factor--an introduction. Cytokine Growth Factor Rev, 2004, 15(4):195-196.
[3] Bowen-Pope DF, Raines EW. History of discovery: platelet-derived growth factor. Arterioscler Thromb Vasc Biol, 2011 , 31(11):2397-2401
[4] Xiang DN, Feng YF, Wang J, Zhang X, Shen JJ, Zou R, Yuan YZ. Platelet-derived growth factor-BB promotes proliferation and migration of retinal microvascular pericytes by up-regulating the expression of C-X-C chemokine receptor types 4. Exp Ther Med. 2019, 18(5):4022-4030.
[5] Pandey P, Khan F, Upadhyay T K, et al. New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies. Biomedicine & Pharmacotherapy, 2023, 161: 114491.
